I’m being a bit unfair as far as Alpha’s go it’s rough to get going but wow it’s GREAT! For starters it’s a Quadra 800 so System 7.1 through 8.1 will work. Also this has full 68040 capabilities so yes that means MMU and YES A/UX (and NetBSD!) will run
As always you can find more on emaculation, the best source for news and info on emulating the Mac.
Additionally you can find the setup guide here.
Many of my Shoebill/Cockatrice III images didn’t work at all. Some at least were picked up as blank disks. I had less luck with freshly created raw/vmdk or qcow2 disks. Not sure at all. My minimal 7 2gb disk worked fine as a donor, and even converting to a vmdk was fine. Sooo YMMV. But hey it’s an Alpha and YES IT CAN WORK.
Another plus is that the idle loop works fine so it won’t burn 100% of your CPU. This could possibly be a great gopher server!? Time will tell.